| Host: | Pichia |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Gene Symbol: | NEFL |
| Gene ID: | 4747 |
| Uniprot ID: | NFL_HUMAN |
| Immunogen Region: | Ser60-Thr250 |
| Immunogen: | Recombinant Human NF-L/NEFL Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ser60-Thr250) of human NF-L/NEFL (Accession #NP_006149.2) fused with no additional amino acid. |
| Immunogen Sequence: | INYKQLQLQERTNIRKCQEL LEQLNGKINLTYRADFKIPM EMTEKMQKSYTAFAIQEMLQ NVFLVFRNNFSSTGWNETIV VRLLDELHQQTVFLKTVLEE KQEERLTWEMSSTALHLKSY YWRVQRYLKLMKYNSYAWMV VRAEIFRNFLIIRRLTRNFQ N |
| Post Translational Modifications | O-glycosylated. Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization. Ubiquitinated in the presence of TRIM2 and UBE2D1. |
| Function | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks. |
| Protein Name | Neurofilament Light PolypeptideNf-L68 Kda Neurofilament ProteinNeurofilament Triplet L Protein |
| Database Links | Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell ProjectionAxonCytoplasmCytoskeleton |
| Alternative Protein Names | Neurofilament Light Polypeptide proteinNf-L protein68 Kda Neurofilament Protein proteinNeurofilament Triplet L Protein proteinNEFL proteinNF68 proteinNFL protein |
Information sourced from Uniprot.org
