Name: Human NF-L/NEFL protein (Recombinant) (No-Tag) (STJP002927)
SKU: STJP002927
Availability: InStock

Human NF-L/NEFL protein (Recombinant) (No-Tag) (STJP002927)

SKU:

STJP002927

£79.50 - £217.50

Host:	Pichia
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation:	Unconjugated
Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	<0.1 EU/Mu g

Gene Symbol:	NEFL
Gene ID:	4747
Uniprot ID:	NFL_HUMAN
Immunogen Region:	Ser60-Thr250
Immunogen:	Recombinant Human NF-L/NEFL Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ser60-Thr250) of human NF-L/NEFL (Accession #NP_006149.2) fused with no additional amino acid.
Immunogen Sequence:	INYKQLQLQERTNIRKCQEL LEQLNGKINLTYRADFKIPM EMTEKMQKSYTAFAIQEMLQ NVFLVFRNNFSSTGWNETIV VRLLDELHQQTVFLKTVLEE KQEERLTWEMSSTALHLKSY YWRVQRYLKLMKYNSYAWMV VRAEIFRNFLIIRRLTRNFQ N

Post Translational Modifications	O-glycosylated. Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization. Ubiquitinated in the presence of TRIM2 and UBE2D1.
Function	Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.
Protein Name	Neurofilament Light Polypeptide Nf-L 68 Kda Neurofilament Protein Neurofilament Triplet L Protein
Database Links	Reactome: R-HSA-438066 Reactome: R-HSA-442982 Reactome: R-HSA-5673001 Reactome: R-HSA-9609736 Reactome: R-HSA-9617324 Reactome: R-HSA-9620244
Cellular Localisation	Cell Projection Axon Cytoplasm Cytoskeleton
Alternative Protein Names	Neurofilament Light Polypeptide protein Nf-L protein 68 Kda Neurofilament Protein protein Neurofilament Triplet L Protein protein NEFL protein NF68 protein NFL protein

Information sourced from Uniprot.org

Model	Name	Host	Application
STJP003773	Human NEFL protein (Recombinant) (N-His) (STJP003773)	E.coli	ELISA/Immunogen/SDS-PAGE/WB
STJP002542	Human IgG2A protein (Recombinant) (No-Tag) (STJP002542)	HEK293 cells
STJP002543	Human IgG3 protein (Recombinant) (No-Tag) (STJP002543)	HEK293 cells
STJP002926	Human CD19 protein (Recombinant) (No-Tag) (STJP002926)	E.coli
STJP000789	Human PIN1 protein (Recombinant) (No tag) (STJP000789)	E.coli

Human NF-L/NEFL protein (Recombinant) (No-Tag) (STJP002927)

General Information