| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human Neuropilin-1/NRP1/VEGF165R/CD304-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Human NRP1 Protein at 2 Mu g/mL (100 Mu L/well) can bind NRP1 Rabbit polyclonal antibody with a linear range of 1.9-98.96 ng/mL.2.Measured by its binding ability in a functional ELISA |
| Gene Symbol: |
NRP1 |
| Gene ID: |
8829 |
| Uniprot ID: |
NRP1_HUMAN |
| Immunogen Region: |
Phe22-Lys644 |
| Immunogen: |
Recombinant Human Neuropilin-1/NRP1/VEGF165R/CD304 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Phe22-Lys644) of human Neuropilin-1/NRP1 (Accession #NP_001019799) fused with a 6×His tag at the C-term |
| Function | Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR. (Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection. Isoform 2: Binds VEGF-165 and may inhibit its binding to cells. May induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. |
| Protein Name | Neuropilin-1Vascular Endothelial Cell Growth Factor 165 ReceptorCd Antigen Cd304 |
| Database Links | Reactome: R-HSA-194306Reactome: R-HSA-376176Reactome: R-HSA-399954Reactome: R-HSA-399955Reactome: R-HSA-399956Reactome: R-HSA-445144Reactome: R-HSA-447041Reactome: R-HSA-9694614 |
| Cellular Localisation | Isoform 2: SecretedMitochondrion MembraneSingle-Pass Type I Membrane ProteinCell MembraneCytoplasm |
| Alternative Protein Names | Neuropilin-1 proteinVascular Endothelial Cell Growth Factor 165 Receptor proteinCd Antigen Cd304 proteinNRP1 proteinNRP proteinVEGF165R protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
