Human Neuroligin-3/NLGN3 protein (Recombinant) (C-His) (STJP001029)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Neuroligin-3/NLGN3 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln 38-Ser 689 ) of human Neuroligin 3/NLGN3 (Accession #NP_061850.2) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human Neuroligin-3/NLGN3-C-His protein was developed in hek293 cells using the region Gln 38-Ser 689. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | NLGN3 |
| Gene ID | 54413 |
| Uniprot ID | NLGN3_HUMAN |
| Immunogen | Recombinant Human Neuroligin-3/NLGN3 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln 38-Ser 689 ) of human Neuroligin 3/NLGN3 (Accession #NP_061850.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Gln 38-Ser 689 |
| Immunogen Sequence | QAPAPTVNTHFGKLRGARVP LPSEILGPVDQYLGVPYAAP PIGEKRFLPPEPPPYWSGIR NATHFPPVCPQNIHTAVPEV MLPVWFTANLDIVATYIQEP NEDCLYLNVYVPTEDGSGAK KQGEDLADNDGDEDEDIRDS GAKPVMVYIHGGSYMEGTGN MIDGSILASYGNVIVITLNY RVGVLGFLSTGDQAAKGNYG LLDQIQALRWVSENIAFFGG DPRRITVFGSGIGASCVSL |
Additional Info
| Function | Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. |
| Protein Name | Neuroligin-3Gliotactin Homolog |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSynapseDetected At Both Glutamatergic And Gabaergic Synapses |
| Alternative Protein Names | Neuroligin-3 proteinGliotactin Homolog proteinNLGN3 proteinKIAA1480 proteinNL3 protein |
Information sourced from Uniprot.org