Human NEUROD1 protein (Recombinant) (N-His-KSI) (STJP010928)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human NEUROD1-N-His-KSI protein was developed from e.coli for the region N-His-KSI. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | NEUROD1 |
| Gene ID | 4760 |
| Uniprot ID | NDF1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr2-Asp356 |
Additional Info
| Function | Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. |
| Protein Name | Neurogenic Differentiation Factor 1NeurodNeurod1Class A Basic Helix-Loop-Helix Protein 3Bhlha3 |
| Database Links | Reactome: R-HSA-210745Reactome: R-HSA-210746 |
| Cellular Localisation | CytoplasmNucleusIn Pancreatic Islet CellsShuttles To The Nucleus In Response To Glucose StimulationColocalizes With Nr0b2 In The Nucleus |
| Alternative Protein Names | Neurogenic Differentiation Factor 1 proteinNeurod proteinNeurod1 proteinClass A Basic Helix-Loop-Helix Protein 3 proteinBhlha3 proteinNEUROD1 proteinBHLHA3 proteinNEUROD protein |
Information sourced from Uniprot.org