Human NEU-1/Sialidase-1 protein (Recombinant) (His-Tag) (STJP017794)

Name: Human NEU-1/Sialidase-1 protein (Recombinant) (His-Tag) (STJP017794)
SKU: STJP017794
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP017794

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Short Description	Recombinant-Human NEU-1/Sialidase-1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.25 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	NEU1
Gene ID	4758
Uniprot ID	NEUR1_HUMAN
Accession Number	NP_000425
Immunogen	Human
Immunogen Region	48-415aa
Immunogen Sequence	MGSSHHHHHH SSGLVPRGSH MGSHMENDFG LVQPLVTMEQ LLWVSGRQIG SVDTFRIPLI TATPRGTLLA FAEARKMSSS DEGAKFIALR RSMDQGSTWS PTAFIVNDGD VPDGLNLGAV VSDVETGVVF LFYSLCAHKA GCQVASTMLV WSKDDGVSWS TPRNLSLDIG TEVFAPGPGS GIQKQREPRK GRLIVCGHGT LERDGVFCLL SDDHGASWRY GSGVSGIP

Tissue Specificity	Highly expressed in pancreas, followed by skeletal muscle, kidney, placenta, heart, lung and liver. Weakly expressed in brain.
Post Translational Modifications	N-glycosylated. Phosphorylation of tyrosine within the internalization signal results in inhibition of sialidase internalization and blockage on the plasma membrane.
Function	Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.
Protein Name	Sialidase-1 Acetylneuraminyl Hydrolase G9 Sialidase Lysosomal Sialidase N-Acetyl-Alpha-Neuraminidase 1
Database Links	Reactome: R-HSA-4085001 Reactome: R-HSA-4341670 Reactome: R-HSA-6798695 Reactome: R-HSA-9840310
Cellular Localisation	Lysosome Membrane Peripheral Membrane Protein Lumenal Side Lysosome Lumen Cell Membrane Cytoplasmic Vesicle Lysosome Localized Not Only On The Inner Side Of The Lysosomal Membrane And In The Lysosomal Lumen But Also On The Plasma Membrane And In Intracellular Vesicles
Alternative Protein Names	Sialidase-1 protein Acetylneuraminyl Hydrolase protein G9 Sialidase protein Lysosomal Sialidase protein N-Acetyl-Alpha-Neuraminidase 1 protein NEU1 protein NANH protein

Information sourced from Uniprot.org