| Tissue Specificity | Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver. |
| Function | Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. |
| Protein Name | Endonuclease 8-Like 2Dna Glycosylase/Ap Lyase Neil2Dna-(Apurinic Or Apyrimidinic Site Lyase Neil2Endonuclease Viii-Like 2Nei Homolog 2Neh2Nei-Like Protein 2 |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-5649702 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Endonuclease 8-Like 2 proteinDna Glycosylase/Ap Lyase Neil2 proteinDna-(Apurinic Or Apyrimidinic Site Lyase Neil2 proteinEndonuclease Viii-Like 2 proteinNei Homolog 2 proteinNeh2 proteinNei-Like Protein 2 proteinNEIL2 protein |
Information sourced from Uniprot.org
