Human NEIL1 protein (Recombinant) (N-His) (STJP005839)

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STJP005839
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NEIL1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NEIL1
Gene ID: 79661
Uniprot ID: NEIL1_HUMAN
Immunogen Region: Ser43-Ala314
Immunogen: Homo sapiens (Human)
Function Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Protein Name Endonuclease 8-Like 1
Dna Glycosylase/Ap Lyase Neil1
Dna-(Apurinic Or Apyrimidinic Site Lyase Neil1
Endonuclease Viii-Like 1
Fpg1
Nei Homolog 1
Neh1
Nei-Like Protein 1
Database Links Reactome: R-HSA-110328
Reactome: R-HSA-110329
Reactome: R-HSA-5649702
Reactome: R-HSA-9616334
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Nucleus
Chromosome
During Mitosis
Associates With Centrosomes And Condensed Chromatin
Alternative Protein Names Endonuclease 8-Like 1 protein
Dna Glycosylase/Ap Lyase Neil1 protein
Dna-(Apurinic Or Apyrimidinic Site Lyase Neil1 protein
Endonuclease Viii-Like 1 protein
Fpg1 protein
Nei Homolog 1 protein
Neh1 protein
Nei-Like Protein 1 protein
NEIL1 protein

Information sourced from Uniprot.org