Human Nectin-2/PVRL2/CD112 protein (Recombinant) (No Tag) (STJP019867)

SKU:
STJP019867
$0.00
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: NECTIN2
Gene ID: 5819
Uniprot ID: NECT2_HUMAN
Immunogen Region: Gln32-Leu360
Immunogen: Recombinant Human Nectin-2/PVRL2/CD112 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln32-Leu360) of Human Nectin-2/PVRL2/CD112 (Accession #Q92692-2) fused with No Tag.
Immunogen Sequence: QDVRVQVLPEVRGQLGGTVE LPCHLLPPVPGLYISLVTWQ RPDAPANHQNVAAFHPKMGP SFPSPKPGSERLSFVSAKQS TGQDTEAELQDATLALHGLT VEDEGNYTCEFATFPKGSVR GMTWLRVIAKPKNQAEAQKV TFSQDPTTVALCISKEGRPP ARISWLSSLDWEAKETQVSG TLAGTVTVTSRFTLVPSGRA DGVTVTCKVEHESFEEPALI PVTLSVRYPPEVSISGYDD
Tissue Specificity Ubiquitous.
Function Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).
Protein Name Nectin-2
Herpes Virus Entry Mediator B
Herpesvirus Entry Mediator B
Hveb
Nectin Cell Adhesion Molecule 2
Poliovirus Receptor-Related Protein 2
Cd Antigen Cd112
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-418990
Reactome: R-HSA-420597
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Nectin-2 protein
Herpes Virus Entry Mediator B protein
Herpesvirus Entry Mediator B protein
Hveb protein
Nectin Cell Adhesion Molecule 2 protein
Poliovirus Receptor-Related Protein 2 protein
Cd Antigen Cd112 protein
NECTIN2 protein
HVEB protein
PRR2 protein
PVRL2 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP019868 Human Nectin-2/PVRL2/CD112 protein (Recombinant) (C-hFc) (STJP019868) HEK293 cells
STJP007122 Human CD112/Nectin-2/PVRL2 protein (Recombinant) (C-His) (STJP007122) Mammalian Cells
STJP005783 Human CD112/Nectin-2/PVRL2 protein (Recombinant) (N-His) (STJP005783) E. coli
STJP019869 Human Nectin-2/PVRL2/CD112 protein (Recombinant) (C-His&Avi) (STJP019869) HEK293 cells
STJP001335 Human Nectin-2/PVRL2/CD112 protein (Recombinant) (C-hFc&His) (STJP001335) HEK293 cells

Related Products

!