• Human Nectin-2/PVRL2/CD112 protein (Recombinant) (C-hFc&His) (STJP001335)

Human Nectin-2/PVRL2/CD112 protein (Recombinant) (C-hFc&His) (STJP001335)

SKU:
STJP001335

$85.73 - $255.83
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Nectin-2/PVRL2/CD112-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Gene Symbol: NECTIN2
Gene ID: 5819
Uniprot ID: NECT2_HUMAN
Immunogen: Recombinant Human Nectin-2/PVRL2/CD112 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln32-Leu360) of human Nectin-2/CD112/PVRL2 (Accession #NP_002847.1) fused with Fc, 6×His tag at the C-termin
Function Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).
Protein Name Nectin-2
Herpes Virus Entry Mediator B
Herpesvirus Entry Mediator B
Hveb
Nectin Cell Adhesion Molecule 2
Poliovirus Receptor-Related Protein 2
Cd Antigen Cd112
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-418990
Reactome: R-HSA-420597
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Nectin-2 protein
Herpes Virus Entry Mediator B protein
Herpesvirus Entry Mediator B protein
Hveb protein
Nectin Cell Adhesion Molecule 2 protein
Poliovirus Receptor-Related Protein 2 protein
Cd Antigen Cd112 protein
NECTIN2 protein
HVEB protein
PRR2 protein
PVRL2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance