| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Human CD112at 1 Mu g/mL (100 Mu L/well) can bind Human CD226 with a linear range of 1.37-81.11 ng/mL. |
| Gene Symbol: | NECTIN2 |
| Gene ID: | 5819 |
| Uniprot ID: | NECT2_HUMAN |
| Immunogen Region: | Gln32-Leu360 |
| Immunogen: | Recombinant Human Nectin-2/PVRL2/CD112 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln32-Leu360) of human Nectin-2/CD112/PVRL2 (Accession #NP_002847.1) fused with Fc, 6×His tag at the C-termin |
| Immunogen Sequence: | QDVRVQVLPEVRGQLGGTVE LPCHLLPPVPGLYISLVTWQ RPDAPANHQNVAAFHPKMGP SFPSPKPGSERLSFVSAKQS TGQDTEAELQDATLALHGLT VEDEGNYTCEFATFPKGSVR GMTWLRVIAKPKNQAEAQKV TFSQDPTTVALCISKEGRPP ARISWLSSLDWEAKETQVSG TLAGTVTVTSRFTLVPSGRA DGVTVTCKVEHESFEEPALI PVTLSVRYPPEVSISGYDD |
| Function | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). |
| Protein Name | Nectin-2Herpes Virus Entry Mediator BHerpesvirus Entry Mediator BHvebNectin Cell Adhesion Molecule 2Poliovirus Receptor-Related Protein 2Cd Antigen Cd112 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-418990Reactome: R-HSA-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Nectin-2 proteinHerpes Virus Entry Mediator B proteinHerpesvirus Entry Mediator B proteinHveb proteinNectin Cell Adhesion Molecule 2 proteinPoliovirus Receptor-Related Protein 2 proteinCd Antigen Cd112 proteinNECTIN2 proteinHVEB proteinPRR2 proteinPVRL2 protein |
Information sourced from Uniprot.org
