| Post Translational Modifications | Phosphorylated by PRKCD.phosphorylation induces activation of NCF1, leading to assembly and activation of the NADPH oxidase complex. |
| Function | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. |
| Protein Name | Neutrophil Cytosol Factor 1Ncf-147 Kda Autosomal Chronic Granulomatous Disease Protein47 Kda Neutrophil Oxidase FactorNcf-47kNeutrophil Nadph Oxidase Factor 1Nox Organizer 2Nox-Organizing Protein 2Sh3 And Px Domain-Containing Protein 1aP47-Phox |
| Database Links | Reactome: R-HSA-1222556Reactome: R-HSA-1236973Reactome: R-HSA-3299685Reactome: R-HSA-4420097Reactome: R-HSA-5668599Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmCytosolMembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Protein Names | Neutrophil Cytosol Factor 1 proteinNcf-1 protein47 Kda Autosomal Chronic Granulomatous Disease Protein protein47 Kda Neutrophil Oxidase Factor proteinNcf-47k proteinNeutrophil Nadph Oxidase Factor 1 proteinNox Organizer 2 proteinNox-Organizing Protein 2 proteinSh3 And Px Domain-Containing Protein 1a proteinP47-Phox proteinNCF1 proteinNOXO2 proteinSH3PXD1A protein |
Information sourced from Uniprot.org
