Human NAXE protein (Recombinant) (N-His) (STJP005715)

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STJP005715
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NAXE-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NAXE
Gene ID: 128240
Uniprot ID: NNRE_HUMAN
Immunogen Region: Gly118-Glu282
Immunogen: Homo sapiens (Human)
Post Translational Modifications Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.
Function Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis.
Protein Name Nad(Ph-Hydrate Epimerase
Apolipoprotein A-I-Binding Protein
Ai-Bp
Nad(Phx Epimerase
Naxe
Yjef N-Terminal Domain-Containing Protein 1
Yjef_n1
Database Links Reactome: R-HSA-197264
Cellular Localisation Mitochondrion
Secreted
In Sperm
Secretion Gradually Increases During Capacitation
Alternative Protein Names Nad(Ph-Hydrate Epimerase protein
Apolipoprotein A-I-Binding Protein protein
Ai-Bp protein
Nad(Phx Epimerase protein
Naxe protein
Yjef N-Terminal Domain-Containing Protein 1 protein
Yjef_n1 protein
NAXE protein
AIBP protein
APOA1BP protein
YJEFN1 protein

Information sourced from Uniprot.org

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