Human MYOCD protein (Recombinant) (N-His-SUMO & C-Strep) (STJP007398)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MYOCD-N-His-SUMO & C-Strep protein was developed from e.coli for the region N-His-SUMO & C-Strep. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MYOCD |
| Gene ID | 93649 |
| Uniprot ID | MYCD_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr2-Gly139 |
Additional Info
| Post Translational Modifications | Ubiquitinated.by STUB1/CHIP at the C-terminus, leading to its degradation by the proteasome. Phosphorylation by GSK3B is required for STUB1/CHIP-mediated ubiquitination. Phosphorylation negatively regulates the intrinsic myocardin transcriptional activity. Phosphorylated.by GSK3B. |
| Function | Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis). Positively regulates the transcription of genes involved in vascular smooth muscle contraction. |
| Protein Name | Myocardin |
| Database Links | Reactome: R-HSA-9733709 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Myocardin proteinMYOCD proteinMYCD protein |
Information sourced from Uniprot.org