Human MYL12B protein (Recombinant) (His-Tag) (STJP017687)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MYL12B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 40% Glycerol, 2mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MYL12B |
| Gene ID | 103910 |
| Uniprot ID | ML12B_HUMAN |
| Accession Number | NP_001138417 |
| Immunogen | Human |
| Immunogen Region | 1-172aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitously expressed in various hematopoietic cells. |
| Post Translational Modifications | Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is reduced following epigallocatechin-3-O-gallate treatment. |
| Function | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. |
| Protein Name | Myosin Regulatory Light Chain 12bMlc-2aMlc-2Myosin Regulatory Light Chain 2-B - Smooth Muscle IsoformMyosin Regulatory Light Chain 20 KdaMlc20Myosin Regulatory Light Chain Mrlc2Shujun-1 |
| Database Links | Reactome: R-HSA-3928663Reactome: R-HSA-416572Reactome: R-HSA-445355Reactome: R-HSA-5625740Reactome: R-HSA-5625900Reactome: R-HSA-5627117Reactome: R-HSA-5627123 |
| Cellular Localisation | |
| Alternative Protein Names | Myosin Regulatory Light Chain 12b proteinMlc-2a proteinMlc-2 proteinMyosin Regulatory Light Chain 2-B - Smooth Muscle Isoform proteinMyosin Regulatory Light Chain 20 Kda proteinMlc20 proteinMyosin Regulatory Light Chain Mrlc2 proteinShujun-1 proteinMYL12B proteinMRLC2 proteinMYLC2B protein |
Information sourced from Uniprot.org