Human MTR (5-Methyltetrahydrofolate Homocysteine Methyltransferase) Sandwich ELISA Kit Ready-To-Use Kit (STJE0017157)

Human MTR (5-Methyltetrahydrofolate Homocysteine Methyltransferase) Sandwich ELISA Kit Ready-To-Use Kit (STJE0017157)

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STJE0017157
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.115ng/mL
Detection Limit: 0.312-20ng/mL
Short Description : This MTR Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: MTR
Gene ID: 4548
Uniprot ID: METH_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Widely expressed. Expressed at the highest levels in pancreas, heart, brain, skeletal muscle and placenta. Expressed at lower levels in lung, liver and kidney.
Post Translational Modifications
Function Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
Protein Name Methionine Synthase
Ms
5-Methyltetrahydrofolate--Homocysteine Methyltransferase
Cobalamin-Dependent Methionine Synthase
Vitamin-B12 Dependent Methionine Synthase
Database Links Reactome: R-HSA-156581
Reactome: R-HSA-1614635
Reactome: R-HSA-3359467
Reactome: R-HSA-3359469
Reactome: R-HSA-9013407
Reactome: R-HSA-9759218
Cellular Localisation Cytoplasm
Alternative ELISA Names Methionine Synthase ELISA kit
Ms ELISA kit
5-Methyltetrahydrofolate--Homocysteine Methyltransferase ELISA kit
Cobalamin-Dependent Methionine Synthase ELISA kit
Vitamin-B12 Dependent Methionine Synthase ELISA kit
MTR ELISA kit
output

Information sourced from Uniprot.org

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