| Tissue Specificity | Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus. |
| Post Translational Modifications | |
| Function | High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Possibly involved in sleep induction, by melatonin activation of the potassium channel KCNMA1/BK and the dissociation of G-beta and G-gamma subunits, thereby decreasing synaptic transmission. |
| Protein Name | Melatonin Receptor Type 1aMel-1a-RMel1a Receptor |
| Database Links | Reactome: R-HSA-373076Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative ELISA Names | Melatonin Receptor Type 1a ELISA kitMel-1a-R ELISA kitMel1a Receptor ELISA kitMTNR1A ELISA kit |
| output | |
Information sourced from Uniprot.org