Human MRGBP protein (Recombinant) (His-Tag) (STJP017439)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MRGBP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% Glycerol, 0.2M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MRGBP |
| Gene ID | 55257 |
| Uniprot ID | MRGBP_HUMAN |
| Accession Number | NP_060740 |
| Immunogen | Human |
| Immunogen Region | 1-204aa |
| Immunogen Sequence |
Additional Info
| Function | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. |
| Protein Name | Mrg/Morf4l-Binding ProteinMrg-Binding ProteinUp-Regulated In Colon Cancer 4Urcc4 |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Mrg/Morf4l-Binding Protein proteinMrg-Binding Protein proteinUp-Regulated In Colon Cancer 4 proteinUrcc4 proteinMRGBP proteinC20orf20 protein |
Information sourced from Uniprot.org