Human MP1/LAMTOR3 protein (Recombinant) (His-Tag) (STJP016944)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MP1/LAMTOR3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 5mM DTT, 100mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LAMTOR3 |
| Gene ID | 8649 |
| Uniprot ID | LTOR3_HUMAN |
| Accession Number | NP_068805 |
| Immunogen | Human |
| Immunogen Region | 1-124aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MADDLKRFLY KKLPSVEGLH AIVVSDRDGV PVIKVANDNA PEHALRPGFL STFALATDQG SKLGLSKNKS IICYYNTYQV VQFNRLPLVV SFIASSSANT GLIVSLEKEL APLFEELRQV VEVS |
Additional Info
| Function | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. |
| Protein Name | Ragulator Complex Protein Lamtor3Late Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 3Mek-Binding Partner 1Mp1Mitogen-Activated Protein Kinase Kinase 1-Interacting Protein 1Mitogen-Activated Protein Kinase Scaffold Protein 1 |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-165159Reactome: R-HSA-166208Reactome: R-HSA-380972Reactome: R-HSA-5628897Reactome: R-HSA-5674135Reactome: R-HSA-6798695Reactome: R-HSA-8943724Reactome: R-HSA-9639288 |
| Cellular Localisation | Late Endosome MembranePeripheral Membrane ProteinCytoplasmic SideRecruited To Lysosome And Endosome Membranes By Lamtor1 |
| Alternative Protein Names | Ragulator Complex Protein Lamtor3 proteinLate Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 3 proteinMek-Binding Partner 1 proteinMp1 proteinMitogen-Activated Protein Kinase Kinase 1-Interacting Protein 1 proteinMitogen-Activated Protein Kinase Scaffold Protein 1 proteinLAMTOR3 proteinMAP2K1IP1 proteinMAPKSP1 proteinPRO2783 protein |
Information sourced from Uniprot.org