| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.01 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its ability to inhibit proliferation of MPC-11 cells. The ED50 for this effect is 3.215-12.86 ng/mL, corresponding to a specific activity of 7.78×104~3.11×105 units/mg. |
| Gene Symbol: | INHBA |
| Gene ID: | 3624 |
| Uniprot ID: | INHBA_HUMAN |
| Immunogen Region: | Gly311-Ser426 |
| Immunogen: | Recombinant Human/Mouse/Rat mature Activin A/INHBA Protein is produced by CHO cells expression system. The target protein is expressed with sequence (Gly311-Ser426) of Human/Mouse/Rat mature Activin A/INHBA (Accession #NP_002183.1) fused with a His t |
| Immunogen Sequence: | LGSFVHCEPCDEKALSMCPP SPLGCELVKEPGCGCCMTCA LAEGQSCGVYTERCAQGLRC LPRQDEEKPLHALLHGRGVC LNEKSYREQVKIERDSREHE EPTTSEMAEETYSPKIFRPK HTRISELKAEAVKKDRRKKL TQSKFVGGAENTAHPRIISA PEMRQESEQGPCRRHMEASL QELKASPRMVPRAVYLPNCD RKGFYKRKQCKPSRGRKRGI CWCVDKYGMKLPGMEYVDG |
| Function | Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. |
| Protein Name | Inhibin Beta A Chain Activin Beta-A Chain Erythroid Differentiation Protein Edf |
| Database Links | Reactome: R-HSA-1502540 Reactome: R-HSA-201451 Reactome: R-HSA-209822 Reactome: R-HSA-2473224 Reactome: R-HSA-9839406 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Inhibin Beta A Chain protein Activin Beta-A Chain protein Erythroid Differentiation Protein protein Edf protein INHBA protein |
Information sourced from Uniprot.org
