| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
Measured by its ability to induce p38 MAPK activation in 3T3 L1 mouse embryonic fibroblast adipose-like cells. 0.1 Mu g/mL of Recombinant Human Irisin can effectively induce p38 MAPK activation. |
| Gene Symbol: |
FNDC5 |
| Gene ID: |
252995 |
| Uniprot ID: |
FNDC5_HUMAN |
| Immunogen Region: |
Asp32-Glu143 |
| Immunogen: |
Recombinant Human/Mouse/Rat Irisin/FNDC5 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp32-Glu143) of Human/Mouse/Rat Irisin (Accession #NP_715637.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
DSPSAPVNVTVRHLKANSAV VSWDVLEDEVVIGFAISQQK KDVRMLRFIQEVNTTTRSCA LWDLEEDTEYIVHVQAISIQ GQSPASEPVLFKTPREAEKM ASKNKDEVTMKE |
| Post Translational Modifications | The extracellular domain is cleaved and released from the cell membrane. N-Glycosylated. |
| Function | Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue. |
| Protein Name | Fibronectin Type Iii Domain-Containing Protein 5Fibronectin Type Iii Repeat-Containing Protein 2 Cleaved Into - Irisin |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPeroxisome MembraneImported In Peroxisomes Through The Pex5 Receptor PathwayIrisin: SecretedDetected In The Blood Of Individuals Subjected To Endurance Exercise |
| Alternative Protein Names | Fibronectin Type Iii Domain-Containing Protein 5 proteinFibronectin Type Iii Repeat-Containing Protein 2 Cleaved Into - Irisin proteinFNDC5 proteinFRCP2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
