Human MIP-3 Alpha (MIP-3 Alpha) Antibody Pair (STJAP00959)
SPECIFICATIONS
HostGoat/Mouse
ConjugationUnconjugated/Biotin
General Information
| Short Description | This MIP-3 Alpha antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Goat/Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL/0.5-4ug/mL |
| Dilution Range | 1:1000-1:10000 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
| Detection | Colorimetric method;ELISA;Sandwich |
Target Information
| Gene Symbol | CCL20 |
| Gene ID | 6364 |
| Uniprot ID | CCL20_HUMAN |
| Sample Type | Serum, plasma and other biological fluids |
Additional Info
| Post Translational Modifications | C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes. |
| Function | Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213. |
| Protein Name | C-C Motif Chemokine 20Beta-Chemokine Exodus-1Cc Chemokine LarcLiver And Activation-Regulated ChemokineMacrophage Inflammatory Protein 3 AlphaMip-3-AlphaSmall-Inducible Cytokine A20 Cleaved Into - Ccl20(1-67 - Ccl20(1-64 - Ccl20(2-70 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594Reactome: R-HSA-6783783 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | C-C Motif Chemokine 20 antibody pairBeta-Chemokine Exodus-1 antibody pairCc Chemokine Larc antibody pairLiver And Activation-Regulated Chemokine antibody pairMacrophage Inflammatory Protein 3 Alpha antibody pairMip-3-Alpha antibody pairSmall-Inducible Cytokine A20 Cleaved Into - Ccl20(1-67 - Ccl20(1-64 - Ccl20(2-70 antibody pairCCL20 antibody pairLARC antibody pairMIP3A antibody pairSCYA20 antibody pair |
Information sourced from Uniprot.org