Human MINPP1 protein (Recombinant) (C-His) (STJP013763)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MINPP1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | MINPP1 |
| Gene ID | 9562 |
| Uniprot ID | MINP1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser31-Leu487 |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP52OH) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology. Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant. By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis. May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of hemoglobin. |
| Protein Name | Multiple Inositol Polyphosphate Phosphatase 12 -3-Bisphosphoglycerate 3-Phosphatase2 -3-Bpg Phosphatase |
| Database Links | Reactome: R-HSA-1855231 |
| Cellular Localisation | Endoplasmic Reticulum LumenSecretedCell MembraneAlso Associated With The Plasma Membrane In Erythrocytes |
| Alternative Protein Names | Multiple Inositol Polyphosphate Phosphatase 1 protein2 -3-Bisphosphoglycerate 3-Phosphatase protein2 -3-Bpg Phosphatase proteinMINPP1 proteinMIPP proteinUNQ900 proteinPRO1917 protein |
Information sourced from Uniprot.org