| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: |
MICB |
| Gene ID: |
4277 |
| Uniprot ID: |
MICB_HUMAN |
| Immunogen Region: |
Ala23-Gly298 |
| Immunogen: |
Recombinant Human MIC-B Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ala23-Gly298) of human MICB (Accession #NP_005922.2) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Sequence: |
AEPHSLRYNLMVLSQDGSVQ SGFLAEGHLDGQPFLRYDRQ KRRAKPQGQWAENVLGAKTW DTETEDLTENGQDLRRTLTH IKDQKGGLHSLQEIRVCEIH EDSSTRGSRHFYYDGELFLS QNLETQESTVPQSSRAQTLA MNVTNFWKEDAMKTKTHYRA MQADCLQKLQRYLKSGVAIR RTVPPMVNVTCSEVSEGNIT VTCRASSFYPRNITLTWRQD GVSLSHNTQQWGDVLPDGN |
| Tissue Specificity | Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue. |
| Post Translational Modifications | Proteolytically cleaved and released from the cell surface of tumor cells. |
| Function | Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8+ alphabeta T-cells. Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production. |
| Protein Name | Mhc Class I Polypeptide-Related Sequence BMic-B |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinBinding To Human Cytomegalovirus Glycoprotein Ul16 Causes Sequestration In The Endoplasmic Reticulum |
| Alternative Protein Names | Mhc Class I Polypeptide-Related Sequence B proteinMic-B proteinMICB proteinPERB11.2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
