| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human MIC-B-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation. |
| Gene Symbol: |
MICB |
| Gene ID: |
4277 |
| Uniprot ID: |
MICB_HUMAN |
| Immunogen Region: |
Ala23-Gly298 |
| Immunogen: |
Recombinant Human MIC-B Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ala23-Gly298) of human MICB (Accession #NP_005922.2) fused with an Fc, 6×His tag at the C-terminus. |
| Tissue Specificity | Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue. |
| Post Translational Modifications | Proteolytically cleaved and released from the cell surface of tumor cells. |
| Function | Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. |
| Protein Name | Mhc Class I Polypeptide-Related Sequence BMic-B |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinBinding To Human Cytomegalovirus Glycoprotein Ul16 Causes Sequestration In The Endoplasmic Reticulum |
| Alternative Protein Names | Mhc Class I Polypeptide-Related Sequence B proteinMic-B proteinMICB proteinPERB11.2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
