| Post Translational Modifications | Phosphorylation at Ser-27 by PKB/AKT1 inactivates its methyltransferase activity via a steric interference mechanism in the active site that locally disrupts the catalytic center. Phosphorylation at Ser-27 does not affect the interaction with WDR4. |
| Function | Catalytic component of METTL1-WDR4 methyltransferase complex that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop. M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay. Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs. Internal N(7)-methylguanine methylation of mRNAs in response to stress promotes their relocalization to stress granules, thereby suppressing their translation. Also methylates a specific subset of miRNAs, such as let-7. N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA). Acts as a regulator of embryonic stem cell self-renewal and differentiation. |
| Protein Name | TrnaGuanine-N(7--MethyltransferaseMethyltransferase-Like Protein 1MrnaGuanine-N(7--MethyltransferaseMirnaGuanine-N(7--MethyltransferaseTrnaGuanine(46-N(7-MethyltransferaseTrna(M7g46-Methyltransferase |
| Database Links | Reactome: R-HSA-6782315 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Trna proteinGuanine-N(7--Methyltransferase proteinMethyltransferase-Like Protein 1 proteinMrna proteinGuanine-N(7--Methyltransferase proteinMirna proteinGuanine-N(7--Methyltransferase proteinTrna proteinGuanine(46-N(7-Methyltransferase proteinTrna(M7g46-Methyltransferase proteinMETTL1 proteinC12orf1 protein |
Information sourced from Uniprot.org
