Human MEOX2 protein (Recombinant) (His-Tag) (STJP018300)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MEOX2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 40% Glycerol, 2mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MEOX2 |
| Gene ID | 4223 |
| Uniprot ID | MEOX2_HUMAN |
| Accession Number | NP_005915 |
| Immunogen | Human |
| Immunogen Region | 188-304aa |
| Immunogen Sequence |
Additional Info
| Function | Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation. Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle. Also acts as a negative regulator of angiogenesis. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells. |
| Protein Name | Homeobox Protein Mox-2Growth Arrest-Specific HomeoboxMesenchyme Homeobox 2 |
| Database Links | |
| Cellular Localisation | NucleusNucleus Speckle |
| Alternative Protein Names | Homeobox Protein Mox-2 proteinGrowth Arrest-Specific Homeobox proteinMesenchyme Homeobox 2 proteinMEOX2 proteinGAX proteinMOX2 protein |
Information sourced from Uniprot.org