Human MEMO1 protein (Recombinant) (His-Tag) (STJP017728)

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STJP017728
£134.50 - £738.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human MEMO1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 50% Glycerol, 5mM DTT, 300mM NaCl, 2mM EDTA
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: MEMO1
Gene ID: 51072
Uniprot ID: MEMO1_HUMAN
Immunogen Region: 1-297aa
Accession Number: NP_057039
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMMSNRV VCREASHAGS WYTASGPQLN AQLEGWLSQV QSTKRPARAI IAPHAGYTYC GSCAAHAYKQ VDPSITRRIF ILGPSHHVPL SRCALSSVDI YRTPLYDLRI DQKIYGELWK TGMFERMSLQ TDEDEHSIEM HLPYTAKAME SHKDEFTIIP VLVGALSESK EQEFGKLFSK YLADPSNLFV VSSDFCHWGQ RFRYSYYD
Function May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.
Protein Name Protein Memo1
C21orf19-Like Protein
Hepatitis C Virus Ns5a-Transactivated Protein 7
Hcv Ns5a-Transactivated Protein 7
Mediator Of Erbb2-Driven Cell Motility 1
Mediator Of Cell Motility 1
Memo-1
Database Links Reactome: R-HSA-6785631
Cellular Localisation
Alternative Protein Names Protein Memo1 protein
C21orf19-Like Protein protein
Hepatitis C Virus Ns5a-Transactivated Protein 7 protein
Hcv Ns5a-Transactivated Protein 7 protein
Mediator Of Erbb2-Driven Cell Motility 1 protein
Mediator Of Cell Motility 1 protein
Memo-1 protein
MEMO1 protein
C2orf4 protein
MEMO protein
NS5ATP7 protein
CGI-27 protein

Information sourced from Uniprot.org

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