Human MDL-1/CLEC5A protein (Recombinant) (His-Tag) (STJP019036)

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STJP019036
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Host: E.coli
Applications: SDS-PAGE/Denatured
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human MDL-1/CLEC5A-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: CLEC5A
Gene ID: 23601
Uniprot ID: CLC5A_HUMAN
Immunogen Region: 28-188aa
Accession Number: NP_037384
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSPQIFNKS NDGFTTTRSY GTVSQIFGSS SPSPNGFITT RSYGTVCPKD WEFYQARCFF LSTSESSWNE SRDFCKGKGS TLAIVNTPEK LKFLQDITDA EKYFIGLIYH REEKRWRWIN NSVFNGNVTN QNQNFNCATI GLTKTFDAAS CDISYRRICE KNAK
Tissue Specificity Highly expressed in bone marrow with lower levels in synovium, lung and bronchus. Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells.
Post Translational Modifications N-glycosylated. Contains sialic acid residues.
Function Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP. This interaction does not result in viral entry, but stimulates pro-inflammatory cytokine release.
Protein Name C-Type Lectin Domain Family 5 Member A
C-Type Lectin Superfamily Member 5
Myeloid Dap12-Associating Lectin 1
Mdl-1
Database Links Reactome: R-HSA-2172127
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names C-Type Lectin Domain Family 5 Member A protein
C-Type Lectin Superfamily Member 5 protein
Myeloid Dap12-Associating Lectin 1 protein
Mdl-1 protein
CLEC5A protein
CLECSF5 protein
MDL1 protein

Information sourced from Uniprot.org

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