Human MCTS1 protein (Recombinant) (His-Tag) (STJP018102)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MCTS1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MCTS1 |
| Gene ID | 28985 |
| Uniprot ID | MCTS1_HUMAN |
| Accession Number | NP_054779 |
| Immunogen | Human |
| Immunogen Region | 1-181aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas. |
| Post Translational Modifications | Phosphorylation is critical for stabilization and promotion of cell proliferation. |
| Function | Translation regulator forming a complex with DENR to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent. Consequently, modulates various unrelated biological processes including cell cycle regulation and DNA damage signaling and repair. Notably, it positively regulates interferon gamma immunity to mycobacteria by enhancing the translation of JAK2. |
| Protein Name | Malignant T-Cell-Amplified Sequence 1Mct-1Multiple Copies T-Cell Malignancies |
| Database Links | |
| Cellular Localisation | CytoplasmNuclear Relocalization After Dna Damage |
| Alternative Protein Names | Malignant T-Cell-Amplified Sequence 1 proteinMct-1 proteinMultiple Copies T-Cell Malignancies proteinMCTS1 proteinMCT1 protein |
Information sourced from Uniprot.org