Human MCM8 protein (Recombinant) (N-His) (STJP008007)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MCM8-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MCM8 |
| Gene ID | 84515 |
| Uniprot ID | MCM8_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser90-Lys366 |
Additional Info
| Function | Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Probably by regulating HR, plays a key role during gametogenesis. Stabilizes MCM9 protein. |
| Protein Name | Dna Helicase Mcm8Minichromosome Maintenance 8 |
| Database Links | Reactome: R-HSA-113507Reactome: R-HSA-176187Reactome: R-HSA-176974Reactome: R-HSA-68689Reactome: R-HSA-68949Reactome: R-HSA-68962 |
| Cellular Localisation | NucleusChromosomeLocalizes To Nuclear FociLocalizes To Double-Stranded Dna BreaksBinds Chromatin Throughout The Cell Cycle |
| Alternative Protein Names | Dna Helicase Mcm8 proteinMinichromosome Maintenance 8 proteinMCM8 proteinC20orf154 protein |
Information sourced from Uniprot.org