Name: Human MCM8 protein (Recombinant) (N-His) (STJP008007)
SKU: STJP008007
Availability: InStock

Human MCM8 protein (Recombinant) (N-His) (STJP008007)

SKU:

STJP008007

£328.50 - £1,437.50

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Host:	E. coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description :	Recombinant-Human MCM8-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.

Formulation:	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.

Function	Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Probably by regulating HR, plays a key role during gametogenesis. Stabilizes MCM9 protein.
Protein Name	Dna Helicase Mcm8 Minichromosome Maintenance 8
Database Links	Reactome: R-HSA-113507 Reactome: R-HSA-176187 Reactome: R-HSA-176974 Reactome: R-HSA-68689 Reactome: R-HSA-68949 Reactome: R-HSA-68962
Cellular Localisation	Nucleus Chromosome Localizes To Nuclear Foci Localizes To Double-Stranded Dna Breaks Binds Chromatin Throughout The Cell Cycle
Alternative Protein Names	Dna Helicase Mcm8 protein Minichromosome Maintenance 8 protein MCM8 protein C20orf154 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP005172	Human COL10A1, N-His protein (Recombinant) (N-His) (STJP005172)	E. coli
STJP004723	Human WAS protein (Recombinant) (N-His) (STJP004723)	E. coli
STJP011684	Human OTUD4 protein (Recombinant) (N-His) (STJP011684)	E. coli
STJP011639	Human ERFE protein (Recombinant) (N-His) (STJP011639)	E. coli
STJP011680	Human TMED3 protein (Recombinant) (N-His) (STJP011680)	E. coli

Human MCM8 protein (Recombinant) (N-His) (STJP008007)

General Information