Human MBP-C/MBL-2 protein (Recombinant) (C-His) (STJP000871)

SKU:

STJP000871

£97.50 - £340.50

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human MBP-C/MBL-2-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:

Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.

Gene Symbol:	MBL2
Gene ID:	4153
Uniprot ID:	MBL2_HUMAN
Immunogen:	Recombinant Human MBP-C/MBL-2 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Glu21-Ile248) of human MBL2/MBL/COLEC1 (Accession #NP_000233.1) fused with a 6×His tag at the C-terminus.

Tissue Specificity	Plasma protein produced mainly in the liver.
Function	Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response.
Protein Name	Mannose-Binding Protein C Mbp-C Collectin-1 Mbp1 Mannan-Binding Protein Mannose-Binding Lectin
Database Links	Reactome: R-HSA-166662 Reactome: R-HSA-166663 Reactome: R-HSA-9705671
Cellular Localisation	Secreted
Alternative Protein Names	Mannose-Binding Protein C protein Mbp-C protein Collectin-1 protein Mbp1 protein Mannan-Binding Protein protein Mannose-Binding Lectin protein MBL2 protein COLEC1 protein MBL protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance