Human MBP-C/MBL-2 protein (Recombinant) (C-His) (STJP000871)

Human MBP-C/MBL-2 protein (Recombinant) (C-His) (STJP000871)

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STJP000871
£106.50 - £342.50
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Gene Symbol: MBL2
Gene ID: 4153
Uniprot ID: MBL2_HUMAN
Immunogen: Recombinant Human MBP-C/MBL-2 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Glu21-Ile248) of human MBL2/MBL/COLEC1 (Accession #NP_000233.1) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: ETVTCEDAQKTCPAVIACSS PGINGFPGKDGRDGTKGEKG EPGQGLRGLQGPPGKLGPPG NPGPSGSPGPKGQKGDPGKS PDGDSSLAASERKALQTEMA RIKKWLTFSLGKQVGNKFFL TNGEIMTFEKVKALCVKFQA SVATPRNAAENGAIQNLIKE EAFLGITDEKTEGQFVDLTG NRLTYTNWNEGEPNNAGSDE DCVLLLKNGQWNDVPCSTSH LAVCEFPI
Tissue Specificity Plasma protein produced mainly in the liver.
Function Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response.
Protein Name Mannose-Binding Protein C
Mbp-C
Collectin-1
Mbp1
Mannan-Binding Protein
Mannose-Binding Lectin
Database Links Reactome: R-HSA-166662
Reactome: R-HSA-166663
Reactome: R-HSA-9705671
Cellular Localisation Secreted
Alternative Protein Names Mannose-Binding Protein C protein
Mbp-C protein
Collectin-1 protein
Mbp1 protein
Mannan-Binding Protein protein
Mannose-Binding Lectin protein
MBL2 protein
COLEC1 protein
MBL protein

Information sourced from Uniprot.org

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