Human Mature TGF-beta 2 protein (Recombinant) (No tag) (STJP002625)

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STJP002625
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.2 Mu m filtered solution of 4 mM HCl.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Immunoreactivity: Recombinant Human Mature TGF-beta 2 Protein inhibit the IL-4-dependent proliferation of HT-2 mouse T cells. The ED50 for this effect is 0.058-0.232 ng/mL, corresponding to a specific activity of 4.3×106~1.72×107 units/mg.
Gene Symbol: TGFB2
Gene ID: 7042
Uniprot ID: TGFB2_HUMAN
Immunogen Region: Ala303-Ser414
Immunogen: Recombinant Human TGF-beta 2 Protein is produced by Human Cell expression system. The target protein is expressed with sequence (Ala303-Ser414) of human TGF-beta 2/TGFB2 (Accession #P61812).
Immunogen Sequence: ALDAAYCFRNVQDNCCLRPL YIDFKRDLGWKWIHEPKGYN ANFCAGACPYLWSSDTQHSR VLSLYNTINPEASASPCCVS QDLEPLTILYYIGKTPKIEQ LSNMIVKSCKCS
Function Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Latency-associated peptide: Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus. Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal.
Protein Name Transforming Growth Factor Beta-2 Proprotein
Cetermin
Glioblastoma-Derived T-Cell Suppressor Factor
G-Tsf Cleaved Into - Latency-Associated Peptide
Lap - Transforming Growth Factor Beta-2
Tgf-Beta-2
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-2129379
Reactome: R-HSA-2173789
Reactome: R-HSA-3000178
Reactome: R-HSA-9839389
Cellular Localisation Latency-Associated Peptide: Secreted
Extracellular Space
Extracellular Matrix
Transforming Growth Factor Beta-2: Secreted
Alternative Protein Names Transforming Growth Factor Beta-2 Proprotein
Cetermin protein
Glioblastoma-Derived T-Cell Suppressor Factor protein
G-Tsf Cleaved Into - Latency-Associated Peptide protein
Lap - Transforming Growth Factor Beta-2 protein
Tgf-Beta-2 protein
TGFB2 protein

Information sourced from Uniprot.org

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