| Host: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of 50mM acetic acid, pH 3.0. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: |
AMH |
| Gene ID: |
268 |
| Uniprot ID: |
MIS_HUMAN |
| Immunogen Region: |
Leu25-Arg560 |
| Immunogen: |
Recombinant Human Mature MIS/AMH Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu25-Arg560) of Human Mature MIS/AMH (Accession #NP_000470.2) fused with a His tag at the N-terminus. |
| Immunogen Sequence: |
SAGATAADGPCALRELSVDL RAERSVLIPETYQANNCQGV CGWPQSDRNPRYGNHVVLLL KMQVRGAALARPPCCVPTAY AGKLLISLSEERISAHHVPN MVATECGCR |
| Tissue Specificity | In ovaries, AMH is detected in granulosa cells of early growing follicles. |
| Post Translational Modifications | Preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active non-covalent complex. Binding of the non-covalent complex to AMHR2 induces dissociation of the pro-region from the mature C-terminal dimer. The N-terminal portion of the protein, despite having no intrinsic activity, has the role of amplifying the activity of the C-terminus. |
| Function | Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation. Also plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression. |
| Protein Name | Muellerian-Inhibiting FactorAnti-Muellerian HormoneAmhMuellerian-Inhibiting SubstanceMis |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-9690406 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Muellerian-Inhibiting Factor proteinAnti-Muellerian Hormone proteinAmh proteinMuellerian-Inhibiting Substance proteinMis proteinAMH proteinMIF protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
