Human Mature BMP-9/GDF-2 protein (Recombinant) (NO-Tag) (STJP020057)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Mature BMP-9/GDF-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser320-Arg429) of Human Mature BMP-9/GDF-2 (Accession # Q9UK05) fused with no tag.
General Information
| Short Description | Recombinant-Human Mature BMP-9/GDF-2-NO-Tag protein was developed in hek293 cells using the region Ser320-Arg429. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | GDF2 |
| Gene ID | 2658 |
| Uniprot ID | GDF2_HUMAN |
| Immunogen | Recombinant Human Mature BMP-9/GDF-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser320-Arg429) of Human Mature BMP-9/GDF-2 (Accession # Q9UK05) fused with no tag. |
| Immunogen Region | Ser320-Arg429 |
| Immunogen Sequence | SAGAGSHCQKTSLRVNFEDI GWDSWIIAPKEYEAYECKGG CFFPLADDVTPTKHAIVQTL VHLKFPTKVGKACCVPTKLS PISVLYKDDMGVPTLKYHYE GMSVAECGCR |
Additional Info
| Tissue Specificity | Detected in blood plasma (at protein level). |
| Post Translational Modifications | A reversible disulfide bond can be formed between the two subunits in the homodimer.this has no effect on GDF2 activity. |
| Function | Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. |
| Protein Name | Growth/Differentiation Factor 2Gdf-2Bone Morphogenetic Protein 9Bmp-9 |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Growth/Differentiation Factor 2 proteinGdf-2 proteinBone Morphogenetic Protein 9 proteinBmp-9 proteinGDF2 proteinBMP9 protein |
Information sourced from Uniprot.org