Post Translational Modifications | S-nitrosylation of Cys-120 inactivates the enzyme. An intrachain disulfide bond can be formed. The protein structure shows that the relevant Cys residues are in a position that would permit formation of a disulfide bond. |
Function | Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. |
Protein Name | S-Adenosylmethionine Synthase Isoform Type-1Adomet Synthase 1Methionine Adenosyltransferase 1Mat 1Methionine Adenosyltransferase I/IiiMat-I/Iii |
Database Links | Reactome: R-HSA-156581Reactome: R-HSA-1614635Reactome: R-HSA-2408508Reactome: R-HSA-5579024 |
Alternative Protein Names | S-Adenosylmethionine Synthase Isoform Type-1 proteinAdomet Synthase 1 proteinMethionine Adenosyltransferase 1 proteinMat 1 proteinMethionine Adenosyltransferase I/Iii proteinMat-I/Iii proteinMAT1A proteinAMS1 proteinMATA1 protein |
Information sourced from Uniprot.org