| Post Translational Modifications | The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Activated by cleavage after Arg-444. The uncleaved zymogen is inactive towards synthetic substrates, but has sufficient activity to effect autocatalytic cleavage. |
| Function | Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. |
| Protein Name | Mannan-Binding Lectin Serine Protease 2Mbl-Associated Serine Protease 2Mannose-Binding Protein-Associated Serine Protease 2Masp-2 Cleaved Into - Mannan-Binding Lectin Serine Protease 2 A Chain - Mannan-Binding Lectin Serine Protease 2 B Chain |
| Database Links | Reactome: R-HSA-166662 O00187-1Reactome: R-HSA-166663 O00187-1Reactome: R-HSA-2855086 O00187-1Reactome: R-HSA-9705671 O00187-1 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Mannan-Binding Lectin Serine Protease 2 proteinMbl-Associated Serine Protease 2 proteinMannose-Binding Protein-Associated Serine Protease 2 proteinMasp-2 Cleaved Into - Mannan-Binding Lectin Serine Protease 2 A Chain - Mannan-Binding Lectin Serine Protease 2 B Chain proteinMASP2 protein |
Information sourced from Uniprot.org
