Human MARCKSL1 protein (Recombinant) (His-Tag) (STJP018148)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MARCKSL1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MARCKSL1 |
| Gene ID | 65108 |
| Uniprot ID | MRP_HUMAN |
| Accession Number | NP_075385 |
| Immunogen | Human |
| Immunogen Region | 1-195aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Phosphorylated. Phosphorylation at Ser-120 and Thr-178 is non-redundantly catalyzed by MAPK8 in vivo. Phosphorylation at Thr-148 is preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the absence of MAPK8. May be phosphorylated by protein kinase C, which disrupts the interaction with calmodulin. |
| Function | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems. |
| Protein Name | Marcks-Related ProteinMarcks-Like Protein 1Macrophage Myristoylated Alanine-Rich C Kinase SubstrateMac-MarcksMacmarcks |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell MembraneLipid-AnchorAssociates With The Membrane Via The Insertion Of The N-Terminal N-Myristoyl Chain And The Partial Insertion Of The Effector DomainAssociation Of The Effector Domain With Membranes May Be Regulated By Ca(2+)/CalmodulinColocalizes With F-Actin At The Leading Edge Of Migrating CellsIn Prostate CancersShows Strong Expression At Apical And/Or Basal Regions Of The Cell And Also Has Weak Cytoplasmic Expression |
| Alternative Protein Names | Marcks-Related Protein proteinMarcks-Like Protein 1 proteinMacrophage Myristoylated Alanine-Rich C Kinase Substrate proteinMac-Marcks proteinMacmarcks proteinMARCKSL1 proteinMLP proteinMRP protein |
Information sourced from Uniprot.org