Human MAP2K3 protein (Recombinant) (N-His) (STJP004768)

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STJP004768
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human MAP2K3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: MAP2K3
Gene ID: 5606
Uniprot ID: MP2K3_HUMAN
Immunogen Region: Val99-Leu343
Immunogen: Homo sapiens (Human)
Post Translational Modifications Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases positively regulates the kinase activity. Phosphorylated by TAOK2. (Microbial infection) Yersinia YopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
Function Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.
Protein Name Dual Specificity Mitogen-Activated Protein Kinase Kinase 3
Map Kinase Kinase 3
Mapkk 3
Mapk/Erk Kinase 3
Mek 3
Stress-Activated Protein Kinase Kinase 2
Sapk Kinase 2
Sapkk-2
Sapkk2
Database Links Reactome: R-HSA-2559580
Reactome: R-HSA-450302
Reactome: R-HSA-5210891 P46734-3
Alternative Protein Names Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 protein
Map Kinase Kinase 3 protein
Mapkk 3 protein
Mapk/Erk Kinase 3 protein
Mek 3 protein
Stress-Activated Protein Kinase Kinase 2 protein
Sapk Kinase 2 protein
Sapkk-2 protein
Sapkk2 protein
MAP2K3 protein
MEK3 protein
MKK3 protein
PRKMK3 protein
SKK2 protein

Information sourced from Uniprot.org