Human MAP2K3 protein (Recombinant) (N-His) (STJP004768)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MAP2K3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MAP2K3 |
| Gene ID | 5606 |
| Uniprot ID | MP2K3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Val99-Leu343 |
Additional Info
| Post Translational Modifications | Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases positively regulates the kinase activity. Phosphorylated by TAOK2. (Microbial infection) Yersinia YopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway. |
| Function | Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. |
| Protein Name | Dual Specificity Mitogen-Activated Protein Kinase Kinase 3Map Kinase Kinase 3Mapkk 3Mapk/Erk Kinase 3Mek 3Stress-Activated Protein Kinase Kinase 2Sapk Kinase 2Sapkk-2Sapkk2 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-450302Reactome: R-HSA-5210891 P46734-3 |
| Cellular Localisation | |
| Alternative Protein Names | Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 proteinMap Kinase Kinase 3 proteinMapkk 3 proteinMapk/Erk Kinase 3 proteinMek 3 proteinStress-Activated Protein Kinase Kinase 2 proteinSapk Kinase 2 proteinSapkk-2 proteinSapkk2 proteinMAP2K3 proteinMEK3 proteinMKK3 proteinPRKMK3 proteinSKK2 protein |
Information sourced from Uniprot.org