| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human MAP2K2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | MAP2K2 |
| Gene ID: | 5605 |
| Uniprot ID: | MP2K2_HUMAN |
| Immunogen Region: | Val86-Pro331 |
| Immunogen: | Homo sapiens (Human) |
| Function | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Activates BRAF in a KSR1 or KSR2-dependent manner.by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation. |
| Protein Name | Dual Specificity Mitogen-Activated Protein Kinase Kinase 2Map Kinase Kinase 2Mapkk 2Erk Activator Kinase 2Mapk/Erk Kinase 2Mek 2 |
| Database Links | Reactome: R-HSA-112411Reactome: R-HSA-170968Reactome: R-HSA-445144Reactome: R-HSA-5210891Reactome: R-HSA-5673000Reactome: R-HSA-5674135Reactome: R-HSA-5674499Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-9649948Reactome: R-HSA-9652169Reactome: R-HSA-9656223 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinMembrane Localization Is Probably Regulated By Its Interaction With Ksr1 |
| Alternative Protein Names | Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 proteinMap Kinase Kinase 2 proteinMapkk 2 proteinErk Activator Kinase 2 proteinMapk/Erk Kinase 2 proteinMek 2 proteinMAP2K2 proteinMEK2 proteinMKK2 proteinPRKMK2 protein |
Information sourced from Uniprot.org
