Tissue Specificity | |
Post Translational Modifications | Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation. |
Function | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
Protein Name | Microtubule-Associated Protein 2Map-2 |
Database Links | |
Cellular Localisation | CytoplasmCytoskeletonCell ProjectionDendrite |
Alternative ELISA Names | Microtubule-Associated Protein 2 ELISA kitMap-2 ELISA kitMAP2 ELISA kit |
output | |
Information sourced from Uniprot.org