Human MAP1B protein (Recombinant) (N-His) (STJP004769)

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STJP004769
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human MAP1B-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: MAP1B
Gene ID: 4131
Uniprot ID: MAP1B_HUMAN
Immunogen Region: Lys414-Glu567
Immunogen: Homo sapiens (Human)
Function Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.
Protein Name Microtubule-Associated Protein 1b
Map-1b Cleaved Into - Map1b Heavy Chain - Map1 Light Chain Lc1
Database Links Reactome: R-HSA-9833110
Cellular Localisation Cytoplasm
Cytoskeleton
Synapse
Cell Projection
Dendritic Spine
Colocalizes With Dapk1 In The Microtubules And Cortical Actin Fibers
Map1 Light Chain Lc1: Cytoplasm
Alternative Protein Names Microtubule-Associated Protein 1b protein
Map-1b Cleaved Into - Map1b Heavy Chain - Map1 Light Chain Lc1 protein
MAP1B protein

Information sourced from Uniprot.org

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