Human M-CSF protein (Recombinant) (His-Tag) (STJP016574)

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STJP016574
€150.60 - €779.40
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human M-CSF-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) 2mM DTT, 10% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
Gene Symbol: CSF1
Gene ID: 1435
Uniprot ID: CSF1_HUMAN
Immunogen Region: 33-190aa
Accession Number: NP_757351.2
Immunogen: Human
Immunogen Sequence: EEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ DVVTKPDCN
Post Translational Modifications N-glycosylated. Isoform 1: N-glycosylated. Isoform 3: N-glycosylated. O-glycosylated.contains chondroitin sulfate. O-glycosylated with core 1 or possibly core 8 glycans. Isoform 1: O-glycosylated.
Function Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
Protein Name Macrophage Colony-Stimulating Factor 1
Csf-1
M-Csf
Mcsf
Lanimostim
Proteoglycan Macrophage Colony-Stimulating Factor
Pg-M-Csf Cleaved Into - Processed Macrophage Colony-Stimulating Factor 1 - Macrophage Colony-Stimulating Factor 1 43 Kda Subunit
Database Links Reactome: R-HSA-381426
Reactome: R-HSA-449836
Reactome: R-HSA-6783783
Reactome: R-HSA-8957275
Reactome: R-HSA-9680350
Reactome: R-HSA-9856649
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Processed Macrophage Colony-Stimulating Factor 1: Secreted
Extracellular Space
Alternative Protein Names Macrophage Colony-Stimulating Factor 1 protein
Csf-1 protein
M-Csf protein
Mcsf protein
Lanimostim protein
Proteoglycan Macrophage Colony-Stimulating Factor protein
Pg-M-Csf Cleaved Into - Processed Macrophage Colony-Stimulating Factor 1 - Macrophage Colony-Stimulating Factor 1 43 Kda Subunit protein
CSF1 protein

Information sourced from Uniprot.org

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