• Human Lung surfactant protein D/SFTPD (E22G) protein (Recombinant) (C-His) (STJP000893)

Human Lung surfactant protein D/SFTPD (E22G) protein (Recombinant) (C-His) (STJP000893)

SKU:
STJP000893

£97.50 - £223.50
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Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Lung surfactant protein D/SFTPD (E22G)-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Gene Symbol: SFTPD
Gene ID: 6441
Uniprot ID: SFTPD_HUMAN
Immunogen: Recombinant Human Lung surfactant protein D/SFTPD (E22G) Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ala21-Phe375 (Glu22Gly) ) of human SFTPD/SP-D/SFTP4 (Accession #NP_003010.4) fused with a 6×His t
Tissue Specificity Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes).
Post Translational Modifications The N-terminus is blocked. Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates. S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.
Function Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
Protein Name Pulmonary Surfactant-Associated Protein D
Psp-D
Sp-D
Collectin-7
Lung Surfactant Protein D
Database Links Reactome: R-HSA-166016
Reactome: R-HSA-168179
Reactome: R-HSA-198933
Reactome: R-HSA-391160
Reactome: R-HSA-5683826
Reactome: R-HSA-5686938
Reactome: R-HSA-5688849
Reactome: R-HSA-5688890
Reactome: R-HSA-9692916
Reactome: R-HSA-9705671
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Surface Film
Alternative Protein Names Pulmonary Surfactant-Associated Protein D protein
Psp-D protein
Sp-D protein
Collectin-7 protein
Lung Surfactant Protein D protein
SFTPD protein
COLEC7 protein
PSPD protein
SFTP4 protein

Information sourced from Uniprot.org

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