Tissue Specificity | Ubiquitously expressed. |
Post Translational Modifications | |
Function | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. |
Protein Name | Leucine-Rich Repeat Flightless-Interacting Protein 1Lrr Flii-Interacting Protein 1Gc-Binding Factor 2Tar Rna-Interacting Protein |
Database Links | Reactome: R-HSA-1839117Reactome: R-HSA-3134973Reactome: R-HSA-5655302 |
Cellular Localisation | NucleusCytoplasm |
Alternative ELISA Names | Leucine-Rich Repeat Flightless-Interacting Protein 1 ELISA kitLrr Flii-Interacting Protein 1 ELISA kitGc-Binding Factor 2 ELISA kitTar Rna-Interacting Protein ELISA kitLRRFIP1 ELISA kitGCF2 ELISA kitTRIP ELISA kit |
output | |
Information sourced from Uniprot.org