| Tissue Specificity | Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells. |
| Post Translational Modifications | Sumoylated by SUMO1 at Lys-270 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation. |
| Function | Orphan nuclear receptor that binds DNA as a monomer to the 5'-TCAAGGCCA-3' sequence and controls expression of target genes: regulates key biological processes, such as early embryonic development, cholesterol and bile acid synthesis pathways, as well as liver and pancreas morphogenesis. Ligand-binding causes conformational change which causes recruitment of coactivators, promoting target gene activation. The specific ligand is unknown, but specific phospholipids, such as phosphatidylethanolamine, phosphatidylserine, dilauroyl phosphatidylcholine and diundecanoyl phosphatidylcholine can act as ligand in vitro. Acts as a pioneer transcription factor, which unwraps target DNA from histones and elicits local opening of closed chromatin. Plays a central role during preimplantation stages of embryonic development. Plays a minor role in zygotic genome activation (ZGA) by regulating a small set of two-cell stage genes. Plays a major role in morula development (2-16 cells embryos) by acting as a master regulator at the 8-cell stage, controlling expression of lineage-specifying transcription factors and genes involved in mitosis, telomere maintenance and DNA repair. Zygotic NR5A2 binds to both closed and open chromatin with other transcription factors, often at SINE B1/Alu repeats DNA elements, promoting chromatin accessibility at nearby regulatory regions. Also involved in the epiblast stage of development and embryonic stem cell pluripotency, by promoting expression of POU5F1/OCT4. Regulates other processes later in development, such as formation of connective tissue in lower jaw and middle ear, neural stem cell differentiation, ovarian follicle development and Sertoli cell differentiation. Involved in exocrine pancreas development and acinar cell differentiation. Acts as an essential transcriptional regulator of lipid metabolism. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. Also acts as a negative regulator of inflammation in different organs, such as, liver and pancreas. Protects against intestinal inflammation via its ability to regulate glucocorticoid production. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Acts as a regulator of immunity by promoting lymphocyte T-cell development, proliferation and effector functions. Also involved in resolution of endoplasmic reticulum stress in the liver. Isoform 3: In constrast to isoform 1 and isoform 2, does not induce cholesterol 7-alpha-hydroxylase gene (CYP7A) promoter activity. (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with HNF1A to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII). |
| Protein Name | Nuclear Receptor Subfamily 5 Group A Member 2Alpha-1-Fetoprotein Transcription FactorB1-Binding FactorHb1fCyp7a Promoter-Binding FactorHepatocytic Transcription FactorLiver Receptor Homolog 1Lrh-1 |
| Database Links | Reactome: R-HSA-210747 O00482-1Reactome: R-HSA-383280Reactome: R-HSA-4090294 O00482-2Reactome: R-HSA-9018519 |
| Cellular Localisation | NucleusChromosome |
| Alternative ELISA Names | Nuclear Receptor Subfamily 5 Group A Member 2 ELISA kitAlpha-1-Fetoprotein Transcription Factor ELISA kitB1-Binding Factor ELISA kitHb1f ELISA kitCyp7a Promoter-Binding Factor ELISA kitHepatocytic Transcription Factor ELISA kitLiver Receptor Homolog 1 ELISA kitLrh-1 ELISA kitNR5A2 ELISA kitB1F ELISA kitCPF ELISA kitFTF ELISA kit |
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Information sourced from Uniprot.org
