Human LPXN protein (Recombinant) (N-His) (STJP010710)

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STJP010710
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human LPXN-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: LPXN
Gene ID: 9404
Uniprot ID: LPXN_HUMAN
Immunogen Region: Val147-Leu386
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated on tyrosine residues. Phosphorylation on Tyr-72 is important for its inhibitory function. Bombesin stimulates phosphorylation on Tyr-22, Tyr-62 and Tyr-72.
Function Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.
Protein Name Leupaxin
Cellular Localisation Cytoplasm
Cell Junction
Focal Adhesion
Nucleus
Perinuclear Region
Cell Projection
Podosome
Cell Membrane
Shuttles Between The Cytoplasm And Nucleus
Recruited To The Cell Membrane Following B-Cell Antigen Receptor (Bcr) Cross-Linking In B-Cells
Enhanced Focal Adhesion Kinase Activity (Ptk2/Fak) Attenuates Its Nuclear Accumulation And Limits Its Ability To Enhance Serum Response Factor (Srf)-Dependent Gene Transcription
Targeting To Focal Adhesions Is Essential For Its Tyrosine Phosphorylation In Response To Bombesin
Alternative Protein Names Leupaxin protein
LPXN protein
LDLP protein

Information sourced from Uniprot.org

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