Human LpPLA2 (Platelet-Activating Factor Acetylhydrolase) Antibody Pair (STJAP00045)

SKU:
STJAP00045-50
£499.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: Mouse/Mouse
Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This LpPLA2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Clonality : Monoclonal/Monoclonal
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Purification: Capture Purification: Protein A or G.
Detection Purification: Protein A or G.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: PLA2G7
Gene ID: 7941
Uniprot ID: PAFA_HUMAN
Immunogen: Capture immunogen: Recombinant Human LpPLA2 protein.
Detection Immunogen: Recombinant Human LpPLA2 protein.
Post Translational Modifications N-glycosylated. Macrophage-derived PLA2G7 carries sialylated complex-type N-glycans that hinder its binding to HDL particles.
Function Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response. At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position. Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups. Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent pro-inflammatory signaling lipid that acts through PTAFR on various innate immune cells. Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled pro-inflammatory effects. As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall. Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage.
Protein Name Platelet-Activating Factor Acetylhydrolase
Paf Acetylhydrolase
1-Alkyl-2-Acetylglycerophosphocholine Esterase
2-Acetyl-1-Alkylglycerophosphocholine Esterase
Group-Viia Phospholipase A2
Gviia-Pla2
Ldl-Associated Phospholipase A2
Ldl-Pla(2
Paf 2-Acylhydrolase
Database Links Reactome: R-HSA-422085
Cellular Localisation Secreted
Extracellular Space
Associates With Both Ldl And Hdl Particles In Plasma
Mainly Associates With Pro-Inflammatory Electronegative Ldl Particles
Alternative Antibody Pair Names Platelet-Activating Factor Acetylhydrolase antibody pair
Paf Acetylhydrolase antibody pair
1-Alkyl-2-Acetylglycerophosphocholine Esterase antibody pair
2-Acetyl-1-Alkylglycerophosphocholine Esterase antibody pair
Group-Viia Phospholipase A2 antibody pair
Gviia-Pla2 antibody pair
Ldl-Associated Phospholipase A2 antibody pair
Ldl-Pla(2 antibody pair
Paf 2-Acylhydrolase antibody pair
PLA2G7 antibody pair
PAFAH antibody pair

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJE0011250 Human PAFAH2 (Platelet Activating Factor Acetylhydrolase 2) Sandwich ELISA Kit Kit (STJE0011250) Human ELISA
STJE0017637 Human PAFAH2 (Platelet Activating Factor Acetylhydrolase 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0017637) Human ELISA
STJE0011251 Mouse PAFAH2 (Platelet Activating Factor Acetylhydrolase 2) Sandwich ELISA Kit Kit (STJE0011251) Mouse ELISA
STJAP00208 Human PF4 (Platelet Factor 4) Antibody Pair (STJAP00208) Mouse/Goat Monoclonal/Polyclonal Human ELISA
STJE0017638 Mouse PAFAH2 (Platelet Activating Factor Acetylhydrolase 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0017638) Mouse ELISA
!