Human LpPLA2 (Platelet-Activating Factor Acetylhydrolase) Antibody Pair (STJAP00045)

SKU:
STJAP00045-50

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Host: Mouse/Mouse
Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: This LpPLA2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Clonality: Monoclonal/Monoclonal
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Purification: Capture Purification: Protein A or G.
Detection Purification: Protein A or G.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: PLA2G7
Gene ID: 7941
Uniprot ID: PAFA_HUMAN
Immunogen: Capture immunogen: Recombinant Human LpPLA2 protein.
Detection Immunogen: Recombinant Human LpPLA2 protein.
Post Translational Modifications N-glycosylated. Macrophage-derived PLA2G7 carries sialylated complex-type N-glycans that hinder its binding to HDL particles.
Function Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response. At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position. Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups. Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent pro-inflammatory signaling lipid that acts through PTAFR on various innate immune cells. Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled pro-inflammatory effects. As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall. Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage.
Protein Name Platelet-Activating Factor Acetylhydrolase
Paf Acetylhydrolase
1-Alkyl-2-Acetylglycerophosphocholine Esterase
2-Acetyl-1-Alkylglycerophosphocholine Esterase
Group-Viia Phospholipase A2
Gviia-Pla2
Ldl-Associated Phospholipase A2
Ldl-Pla(2
Paf 2-Acylhydrolase
Database Links Reactome: R-HSA-422085
Cellular Localisation Secreted
Extracellular Space
Associates With Both Ldl And Hdl Particles In Plasma
Mainly Associates With Pro-Inflammatory Electronegative Ldl Particles
Alternative Antibody Pair Names Platelet-Activating Factor Acetylhydrolase antibody pair
Paf Acetylhydrolase antibody pair
1-Alkyl-2-Acetylglycerophosphocholine Esterase antibody pair
2-Acetyl-1-Alkylglycerophosphocholine Esterase antibody pair
Group-Viia Phospholipase A2 antibody pair
Gviia-Pla2 antibody pair
Ldl-Associated Phospholipase A2 antibody pair
Ldl-Pla(2 antibody pair
Paf 2-Acylhydrolase antibody pair
PLA2G7 antibody pair
PAFAH antibody pair

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance