Human LOX-1/OLR1 protein (Recombinant) (C-His) (STJP001200)

General Information
Product Properties
Target Information
Additional Info
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Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human LOX-1/OLR1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:

Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.

Gene Symbol:	OLR1
Gene ID:	4973
Uniprot ID:	OLR1_HUMAN
Immunogen:	Recombinant Human LOX-1/OLR1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser61-Gln273) of human LOX-1/OLR1 (Accession #NP_002534.1) fused with a 6×His tag at the C-terminus.

Post Translational Modifications	The intrachain disulfide-bonds prevent N-glycosylation at some sites. N-glycosylated.
Function	Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. (Microbial infection) May serve as a receptor for adhesin A variant 3 (nadA) of N.meningitidis.
Protein Name	Oxidized Low-Density Lipoprotein Receptor 1 Ox-Ldl Receptor 1 C-Type Lectin Domain Family 8 Member A Lectin-Like Oxidized Ldl Receptor 1 Lox-1 Lectin-Like Oxldl Receptor 1 Hlox-1 Lectin-Type Oxidized Ldl Receptor 1 Cleaved Into - Oxidized Low-Density Lipoprotein Receptor 1 - Soluble Form
Database Links	Reactome: R-HSA-202733 Reactome: R-HSA-6798695
Cellular Localisation	Cell Membrane Lipid-Anchor Single-Pass Type Ii Membrane Protein Membrane Raft Secreted A Secreted Form Also Exists Localization To Membrane Rafts Requires Palmitoylation
Alternative Protein Names	Oxidized Low-Density Lipoprotein Receptor 1 protein Ox-Ldl Receptor 1 protein C-Type Lectin Domain Family 8 Member A protein Lectin-Like Oxidized Ldl Receptor 1 protein Lox-1 protein Lectin-Like Oxldl Receptor 1 protein Hlox-1 protein Lectin-Type Oxidized Ldl Receptor 1 Cleaved Into - Oxidized Low-Density Lipoprotein Receptor 1 - Soluble Form protein OLR1 protein CLEC8A protein LOX1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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