| Short Description : | Recombinant-Human LMCD1-N-His & C-His protein was developed from e.coli and has a target region of N-His & C-His. For use in research applications. |
| Applications: | ELISA/WB |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, pH 8.0. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | < 1 EU/µg as determined by LAL test. |
| Gene Symbol: | LMCD1 |
| Gene ID: | 29995 |
| Uniprot ID: | LMCD1_HUMAN |
| Immunogen: | Homo sapiens (Human) |
| Immunogen Region: | Met1-Ser365 |
| Function | Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. |
| Protein Name | Lim And Cysteine-Rich Domains Protein 1Dyxin |
| Database Links | Reactome: R-HSA-5683826 |
| Cellular Localisation | CytoplasmNucleusMay Shuttle Between The Cytoplasm And The Nucleus |
| Alternative Protein Names | Lim And Cysteine-Rich Domains Protein 1 proteinDyxin proteinLMCD1 protein |
Information sourced from Uniprot.org